Abstract
OBJECTIVE: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various b-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis. METHODS: Minimal inhibitory concentration was performed using the agar dilution technique and micro-titer method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates. RESULTS: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S.oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100% kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours. CONCLUSION: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.
Article Type
Research Article
First Page
238
Last Page
243
Recommended Citation
Rafay, Akbar M.
(2001)
"Comparative in-vitro activity of trovafloxacin and other related drugs against isolates of streptococcus oralis,"
Saudi Medical Journal: Vol. 22:
Iss.
3, Article 9.
DOI: https://doi.org/10.15537/1658-3175.1389