Elucidation of the mechanisms of hairy-cell localization in tissues and the process of the bone marrow fibrosis in hairy-cell leukemia

Authors

• Khalil A. Aziz, Senior Clinical Scientist, Regional Department of Immunology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, United Kingdom. Tel. +44 (121) 4240185. Fax. +44 (121) 4243229. E-mail: khalil.aziz{at}heartsol.wmids.nhs.uk

Abstract

Hairy cell leukemia is a chronic B cell leukemia with a number of distinctive features including the unusual tissue distribution of the leukemic cells, hairy cells, and the bone marrow fibrosis. We have been working, for a number of years, on the potential mechanisms behind hairy-cell localization in tissues. In this review, it is summarized how our work has shed very important information regarding these mechanisms and led, eventually, to the full elucidation of the process of the bone marrow fibrosis in hairy cell leukemia.

Article Type

Review

First Page

715

Last Page

719

Recommended Citation

Aziz, Khalil A. (2003) "Elucidation of the mechanisms of hairy-cell localization in tissues and the process of the bone marrow fibrosis in hairy-cell leukemia," Saudi Medical Journal: Vol. 24: Iss. 7, Article 2.
DOI: https://doi.org/10.15537/1658-3175.2094