Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy

Authors

• Elif Basgul, Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
• Betul Bahadir, Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
• Varol Celiker, Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
• Ayse H. Karagoz, Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University Ankara 06100, Turkey. Tel. +90 (312) 3051250. E-mail: heves{at}ada.net.tr
• Erhan Hamaloglu, Department of General Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
• Ulku Aypar, Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Abstract

OBJECTIVE: Immunosuppression is directly related to the degree of trauma. The aim of this study is to compare the effects of low and high intra-abdominal pressure on immune response in moderate surgical trauma. METHODS: Twenty-two patients, scheduled for laparoscopic cholecystectomy, were randomly allocated to one of 2 groups according to intra-abdominal pressure: low and high intra-abdominal pressure. This study was conducted in the Hacettepe University Faculty of Medicine, Operation Room, Ankara, Turkey. Serum interleukin (IL)-2 and IL-6 levels were measured. RESULTS: Serum IL-2 showed a significant decrease before the incision in high intra-abdominal pressure group. The increase in serum IL-6 at the end of surgery and postoperatively was lower in low intra-abdominal pressure group. CONCLUSION: These results, can be interpreted as the immune system, are less depressed when there is lower intra-abdominal pressure. This may have clinical implications in immunocompromised patients.

Article Type

Research Article

First Page

1888

Last Page

1891

Recommended Citation

Basgul, Elif; Bahadir, Betul; Celiker, Varol; Karagoz, Ayse H.; Hamaloglu, Erhan; and Aypar, Ulku (2004) "Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy," Saudi Medical Journal: Vol. 25: Iss. 12, Article 18.
DOI: https://doi.org/10.15537/1658-3175.2718