The role of Y chromosome C- band size polymorphism in male infertility with a reference to their effect on the total length of the chromosome

Authors

• Akeel A. Yasseen, Professor/Consultant of Medical Genetics, Department of Pathology and Forensic Medicine, Kufa University, PO Box 18, Kufa, Iraq. E-mail: akeelyasseen{at}hotmail.com
• Salih M. Al-Khafaji, Department of Anatomy and Histology, College of Medicine, Kufa University, Kufa, Iraq.

Abstract

OBJECTIVE: To assess the contribution of chromosome on sperm production. METHODS: During a 2 year period from October 1999 to December 2001 a total of 200 male patients were included in the present study. The study was carried out at Kufa Medical College, Kufa, Iraq. Blood culture, chromosomal harvesting, Giemsa stain, C-band technique and C-band size calculation have been conducted according to the standard methods. RESULTS: No statistical differences have been recorded in the C-band size distribution level among the infertile groups compared to normal control. The functional relationship between C-band, euchromatin and the total length of the Y chromosome showed a strong correlation coefficient among the infertile groups (oligospermia, azoospermia) as well as the normal control. CONCLUSION: In our qualitative study the C-band size of the Y chromosome has no effect on spermatogenesis. The decrease in the size of Y chromosome is due to the decrease in both the heterochromatin and euchromatin regions.

Article Type

Research Article

First Page

452

Last Page

455

Recommended Citation

Yasseen, Akeel A. and Al-Khafaji, Salih M. (2004) "The role of Y chromosome C- band size polymorphism in male infertility with a reference to their effect on the total length of the chromosome," Saudi Medical Journal: Vol. 25: Iss. 4, Article 7.
DOI: https://doi.org/10.15537/1658-3175.2373