Apoptosis and diseases. Regulation and clinical relevance

Authors

• Faris Q. Alenzi, Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, PO Box 2114, Dammam 31451, Kingdom of Saudi Arabia. Tel. +966 (3) 8571000 Ext. 2793. Fax. +966 (3) 8572872. E-mail: faris_alenzi{at}hotmail.com

Abstract

It is increasingly clear that apoptosis plays a central role in the pathogenesis of several human diseases. For instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. Hence, apoptosis may be relevant as therapeutic targets for many human diseases. This article reviews briefly the regulation and the clinical relevance of apoptotic mechanisms in several different human diseases.

Article Type

Review

First Page

1679

Last Page

1690

Recommended Citation

Alenzi, Faris Q. (2005) "Apoptosis and diseases. Regulation and clinical relevance," Saudi Medical Journal: Vol. 26: Iss. 11, Article 1.
DOI: https://doi.org/10.15537/1658-3175.3182