The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion

Authors

• Fatma Saricaoglu, Department of Anesthesiology and Reanimation, Hacettepe University Sihhiye, Ankara 06100,Turkey. Tel. +90 (312) 3051264. Fax. +90 (312) 3109600. E-mail: fatmasaricao{at}yahoo.com
• Seda B. Akinci, Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.
• Varol Celiker, Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.
• Ulku Aypar, Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.

Abstract

OBJECTIVE: In this study, acute normovolemic hemodilution (ANH) and hypervolemic hemodilution (HHD) were compared with no hemodilution with regards to the effectiveness in blood usage and coagulation parameters. METHODS: The study was performed from February to August 2001 at Hacettepe University Hospital, Ankara, Turkey. Thirty patients undergoing hip arthroplasty surgery were prospectively randomized into: ANH group [autologous blood 15 mL kg-1 was withdrawn and replaced by 6% hydroxyethylstarch (HES)] or HHD group (HES was administered without removal of any autologous blood) or the control group (no hemodilution). In all groups, blood was given when hemoglobin concentration was <9 g dl-1. RESULTS: Three groups were clinically similar regarding blood loss, mean arterial pressures and coagulation parameters. But allogeneic transfusion requirements were significantly less in hemodilution groups (20% in ANH, 40% in HHD) compared to the control group (100% of patients). CONCLUSION: We conclude that hemodilution (both ANH and HHD) decreases the demand for homologous blood without adversely affecting hemodynamics or coagulation parameters and HHD seems to be a simple and valuable alternative to ANH in orthopedic patient undergoing hip replacement.

Article Type

Research Article

First Page

792

Last Page

798

Recommended Citation

Saricaoglu, Fatma; Akinci, Seda B.; Celiker, Varol; and Aypar, Ulku (2005) "The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion," Saudi Medical Journal: Vol. 26: Iss. 5, Article 19.
DOI: https://doi.org/10.15537/1658-3175.2965