The role of adenosine triphosphate-regulated potassium channels in propofol-induced beneficial effect on contractile function of hypercholesterolemic isolated rabbit hearts

Authors

• Sule Kalkan, Associate Professor of Pharmacology, Department of Pharmacology, Dokuz Eylul University School of Medicine, Balcova, Izmir 35340, Turkey. Tel. +90 (232) 4123905. Fax. +90 (232) 2599723. E-mail: sule.kalkan{at}deu.edu.tr
• Ozlem Eminoglu, Associate Professor of Pharmacology, Department of Pharmacology, Dokuz Eylul University School of Medicine, Balcova, Izmir 35340, Turkey. Tel. +90 (232) 4123905. Fax. +90 (232) 2599723. E-mail: sule.kalkan{at}deu.edu.tr
• Aylin Akgun, Associate Professor of Pharmacology, Department of Pharmacology, Dokuz Eylul University School of Medicine, Balcova, Izmir 35340, Turkey. Tel. +90 (232) 4123905. Fax. +90 (232) 2599723. E-mail: sule.kalkan{at}deu.edu.tr
• Hulya Guven, Associate Professor of Pharmacology, Department of Pharmacology, Dokuz Eylul University School of Medicine, Balcova, Izmir 35340, Turkey. Tel. +90 (232) 4123905. Fax. +90 (232) 2599723. E-mail: sule.kalkan{at}deu.edu.tr
• Yesim Tuncok, Associate Professor of Pharmacology, Department of Pharmacology, Dokuz Eylul University School of Medicine, Balcova, Izmir 35340, Turkey. Tel. +90 (232) 4123905. Fax. +90 (232) 2599723. E-mail: sule.kalkan{at}deu.edu.tr

Abstract

OBJECTIVE: To investigate the role of adenosine triphosphate-regulated potassium (KATP) channels in the propofol-induced changes in the contractile function of hypercholesterolemic rabbit hearts. METHODS: This study was carried out in the Department of Pharmacology Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey during the period January to December 2003. Twenty-two isolated rabbit hearts were grouped into 4. Group I (n=6) were infused with 50 uM propofol during a 60 minutes perfusion. Group II (n=6) were also infused with 100 uM propofol over the same period. Group III (n=5) was perfused with solutions containing 10 uM glybenclamide and group IV (n=5) 100 uM diazoxide for 5 minutes before and during a 60 minutes infusion with 100 uM propofol. RESULTS: The 50 uM propofol infusion decreased left ventricular pressure (LVP) significantly (p<0.05) but it did not change dP/dtmax and dP/dtmin. The 100 uM propofol infusion caused a significant increase in LVP at 20 minutes. Furthermore, a 100 uM propofol infusion resulted in a significant increase in maximal positive left ventricular pressure (dP/dtmax) and maximal negative left ventricular pressure (dP/dtmin) compared to baseline (p<0.05). The increase in dP/dtmax and dP/dtmin induced by 100 uM propofol was inhibited by glybenclamide (p<0.05), a KATP channel blocker, but was not affected by diazoxide (p>0.05), a KATP channel opener. CONCLUSION: The activation of KATP channels seems to be one of the mechanisms by which propofol induced beneficial effect on contractility of myocardium in hypercholesterolemic rabbit hearts.

Article Type

Research Article

First Page

701

Last Page

706

Recommended Citation

Kalkan, Sule; Eminoglu, Ozlem; Akgun, Aylin; Guven, Hulya; and Tuncok, Yesim (2007) "The role of adenosine triphosphate-regulated potassium channels in propofol-induced beneficial effect on contractile function of hypercholesterolemic isolated rabbit hearts," Saudi Medical Journal: Vol. 28: Iss. 5, Article 5.
DOI: https://doi.org/10.15537/1658-3175.3891