Factors influencing engraftment in autologous peripheral stem cell transplantation. The experience of a local Kuwaiti transplantation center

Authors

• Salem H. Alshemmari, Department of Medicine, Faculty of Medicine, Kuwait University, State of Kuwait, PO Box 24923, Safat 13110, Kuwait. Tel. +96 (5) 5319596. Fax. +96 (5) 5338907. E-mail: salem61{at}gmail.com
• Reem M. Ameen, Department of Medicine, Faculty of Medicine, Kuwait University, State of Kuwait, PO Box 24923, Safat 13110, Kuwait. Tel. +96 (5) 5319596. Fax. +96 (5) 5338907. E-mail: salem61{at}gmail.com
• Jan Gyrafas, Department of Medicine, Faculty of Medicine, Kuwait University, State of Kuwait, PO Box 24923, Safat 13110, Kuwait. Tel. +96 (5) 5319596. Fax. +96 (5) 5338907. E-mail: salem61{at}gmail.com
• Dana A. Alqallaf, Department of Medicine, Faculty of Medicine, Kuwait University, State of Kuwait, PO Box 24923, Safat 13110, Kuwait. Tel. +96 (5) 5319596. Fax. +96 (5) 5338907. E-mail: salem61{at}gmail.com
• Kamlesh P. Sajnani, Department of Medicine, Faculty of Medicine, Kuwait University, State of Kuwait, PO Box 24923, Safat 13110, Kuwait. Tel. +96 (5) 5319596. Fax. +96 (5) 5338907. E-mail: salem61{at}gmail.com

Abstract

OBJECTIVE: To assess factors affecting engraftment among patients with lymphoproliferative disorders treated with high dose-chemotherapy and autologous peripheral blood stem cell transplantation. METHODS: Fifty-four patients with lymphoproliferative disorders were treated from March 2000 to April 2006, at the Hamid Al-Essa Multiorgan Transplant Center, Kuwait. There were 37 males and 17 females, with a median age of 43 years (range 12-60). The cohort included 13 Hodgkin9s lymphoma, 31 non-Hodgkin9s lymphoma, and 10 multiple myeloma cases. RESULTS: The median number of infused CD34+ cells was 1.7 x 106 per kg (0.38-15). The medians for absolute neutrophil count (ANC) and platelet (PLT) engraftment were 12 days (10-15) and 11 days (6-33). The CD34+ cell dose and timing of granulocyte-colony stimulating growth factor administration had no significant influence on ANC engraftment (p=0.3 and p=0.05). CONCLUSION: The results imply that the CD34+ cell dose is the most important predictor of hematopoietic engraftment, namely PLT engraftment. The other factors studied had no clear influence on engraftment kinetics in this cohort.

Article Type

Research Article

First Page

1080

Last Page

1085

Recommended Citation

Alshemmari, Salem H.; Ameen, Reem M.; Gyrafas, Jan; Alqallaf, Dana A.; and Sajnani, Kamlesh P. (2007) "Factors influencing engraftment in autologous peripheral stem cell transplantation. The experience of a local Kuwaiti transplantation center," Saudi Medical Journal: Vol. 28: Iss. 7, Article 18.
DOI: https://doi.org/10.15537/1658-3175.3982