The value of endothelium dependent vasodilatation in diagnosing coronary artery disease and its comparison with the results of routine diagnostic tests

Authors

• Samad Ghaffari, Assistant Professor, Department of Cardiology, Madani heart hospital, Tabriz, Iran. Tel. +98 (411) 3361175. Fax. +98 (411) 3344021. E-mail: ghafaris{at}gmail.com
• Mehrnoosh Toufan, Assistant Professor, Department of Cardiology, Madani heart hospital, Tabriz, Iran. Tel. +98 (411) 3361175. Fax. +98 (411) 3344021. E-mail: ghafaris{at}gmail.com

Abstract

OBJECTIVE: To determine the predictive value of flow-mediated vasodilation (FMD) compared with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging (MPI). METHODS: This study was carried out in Shahid Madani Heart Center, Tabriz, Iran from April 2004 to September 2006. A total of 92 patients with chest pain syndrome were enrolled in this study. Using high resolution ultrasound system endothelial function was evaluated, and the result of the flow-mediated dilation (FMD%) was defined as the percent change in the internal diameter of the brachial artery during reactive hyperemia related to baseline. RESULTS: Coronary artery disease (CAD) was documented in 77 (83.7%) patients. The percentage of FMD was lower in patients with CAD compared with those ± 4.61, p=0.001). In comparison with typical anginal chest pain (sensitivity 46.7%, specificity 80%), exercise stress test (sensitivity 75%, specificity 60%), and MPI (sensitivity 96.5, specificity 55.6%) the receiver operator characteristic curve showed the percentage FMD optimal cut-off value as

Article Type

Research Article

First Page

1344

Last Page

1349

Recommended Citation

Ghaffari, Samad and Toufan, Mehrnoosh (2007) "The value of endothelium dependent vasodilatation in diagnosing coronary artery disease and its comparison with the results of routine diagnostic tests," Saudi Medical Journal: Vol. 28: Iss. 9, Article 5.
DOI: https://doi.org/10.15537/1658-3175.4045