Nalidixic acid-resistant Salmonella enterica serotype typhi infection presenting with sub-intestinal obstruction and mesenteric adenitis

Authors

• Tarig S. Al-Khuwaitir, Chairman, Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia. Tel/Fax. +966 (1) 4783446. E-mail: khuwaitir{at}hotmail.com
• Amin A. Al-Zuhair, Chairman, Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia. Tel/Fax. +966 (1) 4783446. E-mail: khuwaitir{at}hotmail.com
• Ali G. Al-Ghamdi, Chairman, Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia. Tel/Fax. +966 (1) 4783446. E-mail: khuwaitir{at}hotmail.com
• Abdulaziz Khan, Chairman, Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia. Tel/Fax. +966 (1) 4783446. E-mail: khuwaitir{at}hotmail.com

Abstract

Nalidixic acid-resistant Salmonella typhi NARST infections increase minimal inhibitory concentrations of fluoroquinolones, due to chromosomal mutations in the gene encoding DNA gyrase, and can lead to a delayed treatment response. This in turn alters the course of the disease allowing for a protracted period of illness and the occurrence of complications. In this case report, we present a patient from the Indian sub-continent, who was diagnosed with NARST complicated by sub-intestinal obstruction, her diagnosis, treatment, and subsequent recovery.

Article Type

Case Report

First Page

129

Last Page

132

Recommended Citation

Al-Khuwaitir, Tarig S.; Al-Zuhair, Amin A.; Al-Ghamdi, Ali G.; and Khan, Abdulaziz (2008) "Nalidixic acid-resistant Salmonella enterica serotype typhi infection presenting with sub-intestinal obstruction and mesenteric adenitis," Saudi Medical Journal: Vol. 29: Iss. 1, Article 23.
DOI: https://doi.org/10.15537/1658-3175.4204