Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats

Authors

• Umut Ozsoy, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
• Ruya Mutluay, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
• Nezih Oygur, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
• Halide Akbas, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
• Sukru Sindel, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
• Muzaffer Sindel, Department of Anatomy, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Abstract

OBJECTIVE: To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury. METHODS: Thirty-six male Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005. RESULTS: Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates. CONCLUSION: Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.

Article Type

Research Article

First Page

1561

Last Page

1566

Recommended Citation

Ozsoy, Umut; Mutluay, Ruya; Oygur, Nezih; Akbas, Halide; Sindel, Sukru; and Sindel, Muzaffer (2008) "Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats," Saudi Medical Journal: Vol. 29: Iss. 11, Article 5.
DOI: https://doi.org/10.15537/1658-3175.4527