Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes

Authors

• Tunay Senturk, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Emre Sarandol, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Sumeyye Gullulu, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Selda Erdinc, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Osman Ozdabakoglu, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Bulent Ozdemir, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Ibrahim Baran, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Sinan Arslan, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com
• Ali Aydinlar, Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. Tel. +90 (224) 4428191. Fax. +90 (224) 4428191. E-mail: tunaysenturk{at}hotmail.com

Abstract

OBJECTIVE: To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). METHODS: This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation: unstable angina pectoris (UAP) (Braunwald III-B, n=25), non-ST elevation myocardial infarction (NSTEMI) (n=18), and ST-elevation myocardial infarction (STEMI) (n=35). Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay. RESULTS: Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin (r=-0.577, p=0.009, and r=-0.642, p=0.019) and hs-CRP levels (r=-0.614, p=0.03, and r=-0.719, p=0.044). CONCLUSION: Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers.

Article Type

Research Article

First Page

334

Last Page

339

Recommended Citation

Senturk, Tunay; Sarandol, Emre; Gullulu, Sumeyye; Erdinc, Selda; Ozdabakoglu, Osman; Ozdemir, Bulent; Baran, Ibrahim; Arslan, Sinan; and Aydinlar, Ali (2009) "Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes," Saudi Medical Journal: Vol. 30: Iss. 3, Article 3.
DOI: https://doi.org/10.15537/1658-3175.4650