Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies

Authors

• Faten S. Gazzaz, Medical Virology Laboratory, King Abdulaziz University Hospital, PO 80215, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 (2) 6408424. E-mail: Fatengazzaz{at}hotmail.com
• Hisham A. Mosli, Medical Virology Laboratory, King Abdulaziz University Hospital, PO 80215, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 (2) 6408424. E-mail: Fatengazzaz{at}hotmail.com

Abstract

OBJECTIVE: To explore the possibility of finding human papillomavirus (HPV) infection in the prostate tissue of a cohort of Saudi men presenting with benign prostatic hyperplasia (BPH) or prostate cancer. METHODS: A cohort study on prospectively collected tissue samples was conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from March 2007 to December 2008 on a total of 56 male patients, age range 50-93 years (average 68), diagnosed as having BPH or prostate cancer. The HPV DNA hybridization by hybrid capture 2 technology was performed on prostate biopsies of these patients to detect 18 types of HPV infection, and differentiate between 2 HPV DNA groups, the low-risk types, and the high/intermediate risk types. RESULTS: The tissues of all the prostatic biopsies were negative for HPV DNA. CONCLUSION: Our results, using the hybridization test, indicate that it is unlikely that HPV-16 or HPV-18, or the other tested subtypes, enhance the risk of prostate cancer.

Article Type

Research Article

First Page

633

Last Page

637

Recommended Citation

Gazzaz, Faten S. and Mosli, Hisham A. (2009) "Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies," Saudi Medical Journal: Vol. 30: Iss. 5, Article 7.
DOI: https://doi.org/10.15537/1658-3175.4715