High mobility group box-1 and cardiovascular diseases

Authors

• Hua-Sheng Ding, Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University & Yichang Central People's Hospital, Yichang, The People's Republic of China.
• Jun Yang, Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University & Yichang Central People's Hospital, Yichang, The People's Republic of China.

Abstract

High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration. Many recent studies demonstrated that HMGB1 played a pivotal role in cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and myocardial infarction. In this review, we focus on HMGB1 and summarize the association of HMGB1 with cardiovascular diseases.

Article Type

Review

First Page

486

Last Page

489

Recommended Citation

Ding, Hua-Sheng and Yang, Jun (2010) "High mobility group box-1 and cardiovascular diseases," Saudi Medical Journal: Vol. 31: Iss. 5, Article 2.
DOI: https://doi.org/10.15537/1658-3175.5020