Microribonucleic acids and vascular restenosis

Authors

• Zhi-Xing Fan, Department of Cardiology, the First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China. E-mail. 942686648{at}qq.com
• Jian Yang, Department of Cardiology, the First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China. E-mail. 942686648{at}qq.com

Abstract

Microribonucleic acids (miRNAs) are small non-coding RNAs, which control diverse cellular functions by either promoting degradation or inhibiting target messenger RNA translation. An aberrant expression profile of miRNAs has been linked to human diseases, including cardiovascular dysfunction. This review summarizes the latest insights in the identification of vascular-specific miRNAs and the underlying mechanisms for their roles in vascular restenosis mainly by influencing the proliferation and migration of vascular smooth muscle cell. Here, we discuss miRNA-based drug and gene therapy in vascular restenosis.

Article Type

Review

First Page

796

Last Page

801

Recommended Citation

Fan, Zhi-Xing and Yang, Jian (2014) "Microribonucleic acids and vascular restenosis," Saudi Medical Journal: Vol. 35: Iss. 8, Article 3.
DOI: https://doi.org/10.15537/1658-3175.6001