The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility

Authors

• Hongfang Lu, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Jingang Wang, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Baoan Gao, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Shixiong Chen, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Guangming Xiang, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Shaojuan Yang, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Yuan Gong, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China
• Li Guan, From the Institute of Respiratory Diseases, Three Gorges University, Yichang, China

Abstract

Objectives: To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk. Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated. Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p =0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p =0.000 for GG versus CC in the Arab descent. Conclusion: Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.

Article Type

Review

First Page

1400

Last Page

1407

Recommended Citation

Lu, Hongfang; Wang, Jingang; Gao, Baoan; Chen, Shixiong; Xiang, Guangming; Yang, Shaojuan; Gong, Yuan; and Guan, Li (2015) "The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility," Saudi Medical Journal: Vol. 36: Iss. 12, Article 3.
DOI: https://doi.org/10.15537/smj.2015.12.12264