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Abstract

Objectives: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA). Methods: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). C-peptide, glycosylated hemoglobin (HbA1c), bicarbonate, anion gap (AG), free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) levels were measured before and after 7 days of insulin treatment. Daily blood glucose (BG) profiles were recorded. Results: Glycosylated hemoglobin, AG, the mean daily BG, and fasting blood glucose levels were higher, and bicarbonate, FT3, FT4, and TSH levels were lower in group 2 than in group one (all p <0.05). Free triiodothyronine (r=-0.593, p <0.001) and FT4 (r=-0.402, p =0.001) were negatively correlated with HbA1c. Free triiodothyronine (r=-0.438, p <0.001) and FT4 (r=-0.505, p <0.001) were negatively correlated with AG, and FT3 (r=0.503, p <0.001) and FT4 (r=0.448, p <0.001) were positively correlated with bicarbonate. Conclusion: Diabetic ketoacidosis children with ESS have poor diabetic control. Free thyroid hormones are associated with the severity of DKA.

Article Type

Brief Report

First Page

243

Last Page

247

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