An epidemic analysis of hand, foot, and mouth disease in Zunyi, China between 2012 and 2014

Authors

• Weiwei Zhang, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Bo Huang, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Chaokun She, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Yan Liu, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Huabo Tong, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Fengxue Wang, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
• Kaifeng Wu, From the Departments of Pediatric Health Care (Zhang), Pediatrics (Huang), and Laboratory Medicine (She, Liu, Tong, Wang, Wu), The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China

Abstract

Objectives: To re-evaluate the epidemiology of hand, foot, and mouth disease (HFMD) in a non-vaccinated population in Zunyi, China. Methods: We used laboratory-based data from the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China to assess the epidemiology of the HFMD caused by enteroviruses between January 2012 and November 2014. Real-time polymerase chain reaction was used to determine human enteroviruses from a total of 12313 probable cases enrolled in this retrospective study. All analyses were stratified by enterovirus serotype, gender, and age. Results: Virological results were available for 12313 cases of probable HFMD. A total of 5750 cases were positive for viral detection, and the positive rates of infection caused by other enteroviruses was 46.7%, EV71 9%, and CVA16 4.7%. During the study period there was a substantial increase in the occurrence of HFMD. Most of the HFMD patients (87.4%) were aged 0-59 months (median 24; range 0-59). Males showed a higher HFMD prevalence rate (62.4%) than females (37.6%). Conclusion: Enterovirus infection remains an important public health problem and other entroviruses are emerging as the major causative agent of the HFMD in Zunyi, China.

Article Type

Research Article

First Page

593

Last Page

598

Recommended Citation

Zhang, Weiwei; Huang, Bo; She, Chaokun; Liu, Yan; Tong, Huabo; Wang, Fengxue; and Wu, Kaifeng (2015) "An epidemic analysis of hand, foot, and mouth disease in Zunyi, China between 2012 and 2014," Saudi Medical Journal: Vol. 36: Iss. 5, Article 13.
DOI: https://doi.org/10.15537/smj.2015.5.10859