Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension

Authors

• Wenchao Yang, From the School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China
• Zhenmin Zhu, From the School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China
• Jin Wang, From the School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China
• Wei Ye, From the School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China
• Yong Ding, From the School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China

Abstract

Objectives: To evaluate the relationship between alpha epithelial sodium channel (alpha-ENaC) T663A polymorphism and the risk of essential hypertension. Methods: This meta-analysis was conducted between November 2014 and February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effect model. Results: Although subgroup analysis showed that alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals (OR=1.55, 95% CI=1.22-1.98, p =0.0003), our meta-analysis results did not confirm such association overall (OR=1.03, 95% CI=0.92-1.15, p =0.62). The lack of association was further confirmed by the non-superiority test ( p <0.0001). Conclusion: Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension.

Article Type

Review

First Page

1039

Last Page

1045

Recommended Citation

Yang, Wenchao; Zhu, Zhenmin; Wang, Jin; Ye, Wei; and Ding, Yong (2015) "Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension," Saudi Medical Journal: Vol. 36: Iss. 9, Article 3.
DOI: https://doi.org/10.15537/smj.2015.9.11822