Impaired secretion of glucagon-like peptide 1 during oral glucose tolerance test in patients with newly diagnosed type 2 diabetes mellitus

Authors

• Xiao-Li Wang, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Fang Ye, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Jun Li, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Ling-Yun Zhu, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Gang Feng, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Xiang-Yun Chang, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China
• Kan Sun, From the Department of Endocrinology and Metabolism (Wang), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, the Department of Endocrinology and Metabolism (Ye), Hospital of Xinjiang Production and Construction Corps, Xinjiang, the Department of Endocrinology and Metabolism (Wang, Li, Zhu, Feng, Chang, Sun), School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China

Abstract

Objectives: To assess glucagon-like peptide 1 (GLP-1) secretion after oral glucose tolerance tests (OGTTs) in subjects with newly diagnosed type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), and normal glucose tolerance (NGT) to clarify changes in GLP-1 secretion during the course of T2DM. Methods: In this cross sectional study, 80 subjects were divided into the NGT, IGT, and T2DM groups after undergoing a 75 g OGTT from March to December 2014 at the School of Medicine, First Affiliated Hospital, Shihezi University, Xinjiang, China. Plasma total GLP-1 was measured at 0, 30, 60, 120, and 180 minutes. Homeostasis model assessment of insulin resistance (HOMA-IR), islet β-cell function (HOMA-β), Gutt index, Matsuda index, incremental GLP-1 (ΔGLP-1), and areas under the curves of GLP-1 (AUC glp-1 ), glucose (AUC g ), and insulin (AUC ins ) were calculated. Results: Plasma total GLP-1 at 30-120 minutes and ΔGLP-1 at 30-120 minutes were lower in the T2DM group than in the IGT and NGT groups ( p <0.05). Peak GLP-1 levels were 35% lower in the T2DM group than in the NGT group. Plasma total GLP-1, ΔGLP-1, and AUC glp-1 correlated negatively with HOMA-IR and AUC g , and positively with HOMA-β, Gutt index, Matsuda index, and AUC ins ( p <0.05). Conclusion: The GLP-1 secretion after 75 g OGTT was impaired in newly diagnosed T2DM patients, inversely proportional to IR and hyperglycemia, and positively correlated with β-cell function and insulin sensitivity.

Article Type

Research Article

First Page

48

Last Page

54

Recommended Citation

Wang, Xiao-Li; Ye, Fang; Li, Jun; Zhu, Ling-Yun; Feng, Gang; Chang, Xiang-Yun; and Sun, Kan (2016) "Impaired secretion of glucagon-like peptide 1 during oral glucose tolerance test in patients with newly diagnosed type 2 diabetes mellitus," Saudi Medical Journal: Vol. 37: Iss. 1, Article 9.
DOI: https://doi.org/10.15537/smj.2016.1.12035