Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia

Authors

• Qi Wang, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Han Liu, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Siqiao Sun, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Zhihua Cheng, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Yang Zhang, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Xiwei Sun, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Zhongying Wang, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China
• Shuai Wang, From the Department of Vascular Surgery (Wang Q, Sun S, Cheng, Zhang, Sun X, Wang Z, Wang S), and the Department of Respiration (Liu), The First Hospital of Jilin University, Changchun, China

Abstract

Objectives: To confirm whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are indicators for the prognosis of post-amputation patients with critical limb ischemia (CLI). Methods: In this retrospective observational study a total 270 post-amputation patients with CLI were included between January 2010 and December 2014 in the First Hospital of Jilin University, Changchun, China. The neutrophil and lymphocyte counts were recorded before amputations. Neutrophil-to-lymphocyte ratio was calculated and NLR ≥8.08 was defined as elevated. Logistic regression analysis was conducted to test the prognostic value. Results: According to the statistical analysis, it was indicated that NLR ≥8.08 (odds ratio [OR] 26.228, 95% confidence interval [CI]: 5.801-118.583, p <0.001), PLR ≥237.14 (OR: 3.464, 95% CI: 1.289-9.308, p =0.014) and coronary heart disease (OR: 2.739, 95% CI: 1.060-7.082, p =0.038) were the independent prognostic indicators for the patients. Conclusion: Neutrophil-to-lymphocyte ratio, PLR, and coronary heart disease are independent prognostic indicators for post-amputation patients with CLI.

Article Type

Research Article

First Page

24

Last Page

29

Recommended Citation

Wang, Qi; Liu, Han; Sun, Siqiao; Cheng, Zhihua; Zhang, Yang; Sun, Xiwei; Wang, Zhongying; and Wang, Shuai (2017) "Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia," Saudi Medical Journal: Vol. 38: Iss. 1, Article 5.
DOI: https://doi.org/10.15537/smj.2017.1.15936