Wound infiltration with bupivacaine 0.5% with or without adrenaline does not decrease pain after thyroidectomy: A randomized controlled study

Authors

• Ayman A. Mismar, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Mohammad I. Mahseeri, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Mutasim A. Al-Ghazawi, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Firas W. Obeidat, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Mai N. Albsoul, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Mohammad S. Al-Qudah, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan
• Nader M. Albsoul, From the Department of General Surgery (Mismar, Mahseeri, Obeidat, Albsoul M, Al-Qudah, Albsoul N), Faculty of Medicine, and the Department of Biopharmaceutics and Clinical Pharmacy (Al-Ghazawi), Faculty of Pharmacy, The University of Jordan, Amman, Jordan

Abstract

Objectives: To study the effect of local wound infiltration with and without adrenaline on pain perception after thyroidectomy using the visual analog score (VAS). Methods: A prospective randomized controlled double-blinded study was conducted between May 2015 and June 2016 at The University of Jordan Hospital, Amman, Jordan. Eighty-nine patients undergoing planned thyroidectomy were included in the study. Patients were divided randomly into 3 groups: Group A, local wound infiltration with bupivacaine 0.5% was administered; Group B, bupivacaine 0.5% with adrenaline was administered; Group C (control), no infiltration was performed. Standardized thyroidectomies were performed in the 3 groups. Pain perception was measured using VAS at 2, 4, 6, 12, and 24 hours after surgery. A comparison between the 3 groups was carried out. Results: No significant differences among the 3 groups were observed at all time points ( p =0.246). Visual analog scores were significantly lower at 12 and 24 hours after operations. Conclusion: Local wound infiltration with bupivacaine 0.5% does not decrease pain perception after thyroidectomy performed under general anesthesia, and adding adrenaline does not enhance its effect.

Article Type

Research Article

First Page

994

Last Page

999

Recommended Citation

Mismar, Ayman A.; Mahseeri, Mohammad I.; Al-Ghazawi, Mutasim A.; Obeidat, Firas W.; Albsoul, Mai N.; Al-Qudah, Mohammad S.; and Albsoul, Nader M. (2017) "Wound infiltration with bupivacaine 0.5% with or without adrenaline does not decrease pain after thyroidectomy: A randomized controlled study," Saudi Medical Journal: Vol. 38: Iss. 10, Article 3.
DOI: https://doi.org/10.15537/smj.2017.10.20294