Abstract
Objectives: To investigate the frequency of the growth hormone receptor (GHR)-d3 polymorphism in a random sample of Saudi Arabian population from Jazan province, and test the effects of the polymorphism on some anthropometric factors. Methods: This cross-sectional population-based study was conducted during the period from January to April 2017 at the College of Applied Medical Sciences, Jazan University, Southwestern Saudi Arabia. A total of 230 healthy adult male and female volunteers were randomly recruited. Genomic DNA was extracted from the whole blood, and the GHR exon 3 locus was genotyped using multiplex polymerase chain reaction. Results: The distributions of the GHR genotypes were as follows: fl/fl (39.1%), fl/d3 (44.8%), and d3/d3 (16.1%). No statistically significant differences were found between fl/fl, fl/d3, or d3/d3 GHR genotypes in terms of weight ( p =0.90), height ( p =0.12), or body mass index (BMI) ( p =0.83) values. Conclusion: No correlations were found between the GHR-d3 polymorphism and weight, height, or BMI.
Article Type
Research Article
First Page
1090
Last Page
1095
Recommended Citation
Kaabi, Yahia A.
(2017)
"Frequency of the exon 3-deleted/full-length growth hormone receptor polymorphism in Saudi Arabian population,"
Saudi Medical Journal: Vol. 38:
Iss.
11, Article 3.
DOI: https://doi.org/10.15537/smj.2017.11.21109