The serum levels of tumor marker CA19-9, CEA, CA72-4, and NSE in type 2 diabetes without malignancy and the relations to the metabolic control

Authors

• Xiaojing Shang, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China
• Chunqing Song, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China
• Xiaoming Du, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China
• Hailin Shao, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China
• Donghong Xu, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China
• Xiaolai Wang, From the Department of Endocrinology, Tianjin Fourth Central Hospital, and Fourth Center Clinical College, Tianjin Medical University, Tianjin, China

Abstract

Objectives: To investigate whether there is a difference in carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 72-4 (CA72-4), and neuron-specific enolase (NSE) between diabetic and non-diabetic patients. Methods: A retrospective analysis was performed in 268 type 2 diabetic patients and 95 non-diabetic ones, and their serum levels of CA19-9, CEA, CA72-4, and NSE were compared in our endocrine ward at the Tianjin Fourth Central Hospital, Tianjin, China during the period from January to June 2015. The diabetic patients were divided into 4 groups based on glycosylated hemoglobin (HbA1c) levels to investigate the relationship between levels of tumor markers and glucose status. Results: Diabetic patients had higher levels of tumor markers than non-diabetic subjects (CA19-9: 13.0 versus 7.25U/mL, p =0.000; CEA: 2.55 versus 2.25 ng/mL, p =0.012; CA72-4: 1.95 versus 1.50U/mL, p =0.001; NSE: 11.64 versus 10.22ng/mL, p =0.000). CA19-9 levels increased in a stepwise manner with poor diabetes status. CEA levels were increased in patients with HbA1c ≥9% and CA72-4 elevation was predominant in patients with poor glycemic control (HbA1c ≥11%). NSE levels were not associated with metabolic parameters. Conclusion: Serum levels of CA19-9, CEA, CA72-4, and NSE were elevated in type 2 diabetes; however, only CA19-9, CEA, and CA72-4 levels were associated with hyperglycemia.

Article Type

Brief Report

First Page

204

Last Page

208

Recommended Citation

Shang, Xiaojing; Song, Chunqing; Du, Xiaoming; Shao, Hailin; Xu, Donghong; and Wang, Xiaolai (2017) "The serum levels of tumor marker CA19-9, CEA, CA72-4, and NSE in type 2 diabetes without malignancy and the relations to the metabolic control," Saudi Medical Journal: Vol. 38: Iss. 2, Article 15.
DOI: https://doi.org/10.15537/smj.2017.2.15649