Hormone receptor status and survival of medullary breast cancer patients: A Turkish cohort

Authors

• Asude Aksoy, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Hatice Odabas, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Serap Kaya, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Oktay Bozkurt, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Mustafa Degirmenci, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Turkan O. Topcu, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Aydın Aytekin, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Erkan Arpaci, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Nilufer Avci, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Kezban N. Pilanci, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Havva Y. Cinkir, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Yakup Bozkaya, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Yalcin Cirak, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey
• Mahmut Gumus, From the Department of Medical Oncology (Aksoy), Firat University, Medical Faculty, Elazig, Department of Medical Oncology (Odabas), Kartal Dr. Lutfi Kirdar Education and Research Hospital, Department of Medical Oncology (Kaya), Marmara University, Department of Medical Oncology (Cirak), Istanbul Bahcesehir University, Department of Medical Oncology (Gumus), Bezm-I Alem University, Medical Faculty, Department of Medical Oncology (Pilanci), Haseki Education and Research Hospital, Department of Medical Oncology (Bozkaya), Ankara Numune Education Hospital, Istanbul, Department of Medical Oncology (Bozkurt), Erciyes University, Medical Faculty, Kayseri, Department of Medical Oncology (Degirmenci), Tepecik Education State and Research Hospital, Izmir, Department of Medical Oncology (Topcu), Karadeniz Teknik University, Medical Faculty, Trabzon, Department of Medical Oncology (Aytekin), Gazi University, Medical Faculty, Department of Medical Oncology (Cinkir), Ankara Yurtsalan Oncology Hospital, Ankara, Department of Medical Oncology (Arpaci), Bulent Ecevit University, Medical Faculty, Zonguldak, and the Department of Medical Oncology (Avci), Bursa Ali Osman Sonmez Oncology Hospital, Bursa, Turkey

Abstract

Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis ( p <0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis ( p <0.05). However, none of these factors were determined as significant independent prognostic factors for OS ( p >0.05). Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.

Article Type

Research Article

First Page

156

Last Page

162

Recommended Citation

Aksoy, Asude; Odabas, Hatice; Kaya, Serap; Bozkurt, Oktay; Degirmenci, Mustafa; Topcu, Turkan O.; Aytekin, Aydın; Arpaci, Erkan; Avci, Nilufer; Pilanci, Kezban N.; Cinkir, Havva Y.; Bozkaya, Yakup; Cirak, Yalcin; and Gumus, Mahmut (2017) "Hormone receptor status and survival of medullary breast cancer patients: A Turkish cohort," Saudi Medical Journal: Vol. 38: Iss. 2, Article 7.
DOI: https://doi.org/10.15537/smj.2017.2.18055