Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy: A double-blind, randomized and controlled trial

Authors

• Jinguo Wang, From the Department of Urology (Wang J, Zhou) and from the Department of Anesthesiology (Wang N, Wang Y), The First Hospital of Jilin University, Changchun, China
• Na Wang, From the Department of Urology (Wang J, Zhou) and from the Department of Anesthesiology (Wang N, Wang Y), The First Hospital of Jilin University, Changchun, China
• Honglan Zhou, From the Department of Urology (Wang J, Zhou) and from the Department of Anesthesiology (Wang N, Wang Y), The First Hospital of Jilin University, Changchun, China
• Yuanyuan Wang, From the Department of Urology (Wang J, Zhou) and from the Department of Anesthesiology (Wang N, Wang Y), The First Hospital of Jilin University, Changchun, China

Abstract

Objectives: To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy. Methods: The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical, gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded. Results: Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects. Conclusion: Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.

Article Type

Research Article

First Page

1023

Last Page

1027

Recommended Citation

Wang, Jinguo; Wang, Na; Zhou, Honglan; and Wang, Yuanyuan (2018) "Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy: A double-blind, randomized and controlled trial," Saudi Medical Journal: Vol. 39: Iss. 10, Article 10.
DOI: https://doi.org/10.15537/smj.2018.10.22852