Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with reduced/mid-range ejection fraction via VEGF and sVEGFR-1

Authors

• Ismail Erturk, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Kenan Saglam, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Sadi Elasan, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Musa B. Aykan, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Ramazan Acar, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Fatih Yesildal, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Fevzi N. Aydin, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey
• Taner Ozgurtas, From the Department of Internal Medicine (Erturk, Saglam, Aykan, Acar), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, from the Department of Biostatistics (Elasan), 100th Years University Faculty of Medicine, Van, from the Department of Medical Biochemistry (Yesildal), Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, from the Department of Medical Biochemistry (Aydin), Diskapi Training and Research Hospital, Ankara, and from the Department of Medical Biochemistry (Ozgurtas), University of Health Sciences, Gulhane Education and Research Hospital, Ankara, Turkey

Abstract

Objectives: To investigate the clinical significance of VEGF, sVEGFR-1 in heart failure reduced ejection fraction (HFrEF) and heart failure mid-range ejection fraction (HFmrEF) patients. Methods: A total of 104 people consisting of HFrEF and HFmrEF patients (n=54) and healthy (n=50) subjects were included in this comparative cross-sectional study. The study took place in Gulhane Training and Research Hospital, Ankara, Turkey, between 2011 and 2013. Serum VEGF, sVEGFR-1, plasma pro-BNP analysis and transthoracic echocardiography were performed. Results: The average sVEGFR-1 level of the HFrEF and HFmrEF patients was significantly higher than the control group (0.185±0.122; 0.141±0.120; p =0.013). The average sVEGFR-1 level of the HFrEF and HFmrEF patients using beta-blocker was significantly higher than the HFrEF and HFmrEF patients not using it ( p =0.015). There was a significant and positive correlation between sVEGFR-1 and N-terminal pro-brain natriuretic peptide (pro-BNP) levels in the group with HF (r=0.211, p =0.044). Conclusion: It increases awareness about the role of sVEGFR-1 in HFrEF anf HFmrEF patients and the need for further studies. Beta-blocker may have a negative effect on angiogenesis in HFrEF and HFmrEF via increasing sVEGFR-1 levels. Additionally, Pro-BNP may contribute to inhibiting angiogenesis by increasing sVEGFR-1 levels and sVEGFR-1 may be an important biomarker in HFrEF and HFmrEF.

Article Type

Research Article

First Page

1028

Last Page

1034

Recommended Citation

Erturk, Ismail; Saglam, Kenan; Elasan, Sadi; Aykan, Musa B.; Acar, Ramazan; Yesildal, Fatih; Aydin, Fevzi N.; and Ozgurtas, Taner (2018) "Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with reduced/mid-range ejection fraction via VEGF and sVEGFR-1," Saudi Medical Journal: Vol. 39: Iss. 10, Article 11.
DOI: https://doi.org/10.15537/smj.2018.10.22946