The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics

Authors

• Yusni Yusni, From the Department of Physiology (Yusni), Department of Pharmacology (Meutia), Division of Endocrinology Metabolism and Diabetes-Tyroid Center (Zufry, Sucipto), Department of Internal Medicine, and the Department of Opthalmology and Visual Science (Meutia), Dr. Zainoel Abidin General Teaching Hospital, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh, Indonesia
• Hendra Zufry, From the Department of Physiology (Yusni), Department of Pharmacology (Meutia), Division of Endocrinology Metabolism and Diabetes-Tyroid Center (Zufry, Sucipto), Department of Internal Medicine, and the Department of Opthalmology and Visual Science (Meutia), Dr. Zainoel Abidin General Teaching Hospital, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh, Indonesia
• Firdalena Meutia, From the Department of Physiology (Yusni), Department of Pharmacology (Meutia), Division of Endocrinology Metabolism and Diabetes-Tyroid Center (Zufry, Sucipto), Department of Internal Medicine, and the Department of Opthalmology and Visual Science (Meutia), Dr. Zainoel Abidin General Teaching Hospital, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh, Indonesia
• Krishna W. Sucipto, From the Department of Physiology (Yusni), Department of Pharmacology (Meutia), Division of Endocrinology Metabolism and Diabetes-Tyroid Center (Zufry, Sucipto), Department of Internal Medicine, and the Department of Opthalmology and Visual Science (Meutia), Dr. Zainoel Abidin General Teaching Hospital, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh, Indonesia

Abstract

Objectives: To analyze the effect of celery leaf extract on blood glucose and plasma insulin levels in elderly pre-diabetics. Methods: This study was conducted between March and November 2014 at the Faculty of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. A quasi-experimental pretest-posttest with a control group was conducted with elderly pre-diabetic volunteers. The subjects included 16 elderly pre-diabetics older than 60 (6 males and 10 females). The subjects were randomly divided into 2 groups: a control group (placebo-treated) and a treatment group (celery-treated). The treatment consisted of celery leaf extract capsules at the dose of 250 mg, 3 times per day (morning, afternoon and evening), 30 minutes before a meal, for 12 days. Data analysis was performed using the t-test ( p <0.05). Results: There was a significant decrease in pre-prandial plasma glucose levels ( p =0.01) and post-prandial plasma glucose levels ( p =0.00), but no significant increase in plasma insulin levels ( p =0.15) after celery leaf treatment in elderly pre-diabetics. Conclusion: Celery was effective at reducing blood glucose levels, but there was a lack of association between blood glucose levels and plasma insulin levels in elderly pre-diabetics.

Article Type

Research Article

First Page

154

Last Page

160

Recommended Citation

Yusni, Yusni; Zufry, Hendra; Meutia, Firdalena; and Sucipto, Krishna W. (2018) "The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics," Saudi Medical Journal: Vol. 39: Iss. 2, Article 8.
DOI: https://doi.org/10.15537/smj.2018.2.21238