Peripheral venous route for administration of ammonul infusion for treatment of acute hyperammonemia: An experience from a tertiary center in Saudi Arabia

Authors

• Amal M. Alhashem, From the Department of Pediatrics (Alhashem, Salih, Al-Aqeel, Mohamed), Prince Sultan Military Medical City; from the Department of Pediatrics (Mohamed), College of Medicine, AlFaisal University; and from Prince Abdullah bin Khalid Celiac Disease Research Chair (Mohamed), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; and from the Department of Anatomy and Cell Biology (Alhashem, Al-Aqeel), from the Department of Biochemistry and Molecular Biology, (Al-Aqeel), College of Medicine, American University of Beirut, Lebanon
• Rihab M. Salih, From the Department of Pediatrics (Alhashem, Salih, Al-Aqeel, Mohamed), Prince Sultan Military Medical City; from the Department of Pediatrics (Mohamed), College of Medicine, AlFaisal University; and from Prince Abdullah bin Khalid Celiac Disease Research Chair (Mohamed), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; and from the Department of Anatomy and Cell Biology (Alhashem, Al-Aqeel), from the Department of Biochemistry and Molecular Biology, (Al-Aqeel), College of Medicine, American University of Beirut, Lebanon
• Aida I. Al-Aqeel, From the Department of Pediatrics (Alhashem, Salih, Al-Aqeel, Mohamed), Prince Sultan Military Medical City; from the Department of Pediatrics (Mohamed), College of Medicine, AlFaisal University; and from Prince Abdullah bin Khalid Celiac Disease Research Chair (Mohamed), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; and from the Department of Anatomy and Cell Biology (Alhashem, Al-Aqeel), from the Department of Biochemistry and Molecular Biology, (Al-Aqeel), College of Medicine, American University of Beirut, Lebanon
• Sarar Mohamed, From the Department of Pediatrics (Alhashem, Salih, Al-Aqeel, Mohamed), Prince Sultan Military Medical City; from the Department of Pediatrics (Mohamed), College of Medicine, AlFaisal University; and from Prince Abdullah bin Khalid Celiac Disease Research Chair (Mohamed), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; and from the Department of Anatomy and Cell Biology (Alhashem, Al-Aqeel), from the Department of Biochemistry and Molecular Biology, (Al-Aqeel), College of Medicine, American University of Beirut, Lebanon

Abstract

Objectives: To determine the local effects of peripheral Ammonul infusion on the skin and the subcutaneous tissues. Methods: This retrospective study was conducted at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. All children <16 years of age admitted between December 2015 and October 2018 with hyperammonemia and received Ammonul infusion for treatment were recruited. Results: Twenty-one patients received the Ammonul infusion. They were admitted 58 times with acute hyperammonemia during the study period, with an average of 2.8 admissions per patient. The mean age of the included patients was 49.5 months. The most frequent underlying diagnoses were propionic acidemia (n=9), urea cycle disorders (n=5), and intrinsic liver disease (n=3). All participants received Ammonul through peripheral lines except 3 who received it through central lines. No extravasation, burns, or other local side effects were observed in this cohort. Conclusion: This data indicate that the use of Ammonul through a peripheral venous route appears to be safe and not associated with infusion-related local adverse effects.

Article Type

Brief Report

First Page

98

Last Page

101

Recommended Citation

Alhashem, Amal M.; Salih, Rihab M.; Al-Aqeel, Aida I.; and Mohamed, Sarar (2020) "Peripheral venous route for administration of ammonul infusion for treatment of acute hyperammonemia: An experience from a tertiary center in Saudi Arabia," Saudi Medical Journal: Vol. 41: Iss. 1, Article 17.
DOI: https://doi.org/10.15537/smj.2020.1.24760