Role of fine-needle aspiration cytology in evaluating thyroid nodules: A retrospective study from a tertiary care center of Western region, Saudi Arabia

Authors

• Ahmed S. Bahaj, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Haddad H. Alkaff, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Bashair N. Melebari, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Anwar N. Melebari, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Suhail I. Sayed, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Syeddah S. Mujtaba, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Sherif K. Abdelmonim, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Saeed A. Alghamdi, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Fares E. Alghamdi, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Mohammad A. Alessa, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Anas H. Al-Tammas, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Rajab A. Al-Zahrani, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Osama A. Marglani, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• John C. Heaphy, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Osama A. Bawazir, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt
• Ameen Z. Alherabi, From the Head and Neck & Skull Base Surgery Center (Bahaj, Alkaff, Sayed, Abdelmonim, Alghamdi A, Alghamdi FE, Abu Suliman, Alessa, Al-Zahrani, Marglani, Alherabi); from the Department of Pathology (Mujtaba), King Abdullah Medical City, from the Department of Otolaryngology (BN. Melebari, AN. Melebari, Marglani, Alherabi), Head & Neck Surgery; from the Department of Surgery (Bawazir), Pediatric Surgery Section, College of Medicine, Umm Al-Qura University, Makkah, from the Department of Otolaryngology-Head & Neck Surgery (Abi Sheffah, Al-Tammas, Marglani, Heaphy, Alherabi); from the Department of Surgery (Bawazir), King Faisal Specialist Hospital & Research Center, from the Department of Otolaryngology-Head & Neck Surgery (Marglani, Alherabi), International Medical Center, Jeddah, from the Department of Otolaryngology-Head & Neck Surgery (Al-Zahrani), Faculty of Medicine, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia; and from the Department of Otolaryngology-Head & Neck Surgery (Abdelmonim), Faculty of Medicine, Ain Shams University, Cairo, Egypt

Abstract

Objectives: To evaluate the accuracy and efficacy of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules, correlating it with the histopathological findings. Methods: A retrospective evaluation of 314 patients was undertaken at a tertiary referral center of King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia, between 2010-2019. Patients who presented with thyroid swellings underwent ultrasonography and FNAC. If indicated, surgery was performed. The FNAC findings were compared to the final histopathological reports. Results: The findings for FNAC from our data set of 314 patients showed a sensitivity value of 79.8%, specificity of 82.1%, accuracy of 74.8%, positive predictive value of 74.8%, and negative predictive value of 85.9%. Conclusion: Our study showed that FNAC has high sensitivity and specificity in the initial evaluation of patients with thyroid nodules. When guided by ultrasonography, the accuracy can be markedly improved. Molecular markers once widely available can improve the diagnostic power of FNAC to be no less than the histopathologic evaluation of thyroid tissue.

Article Type

Research Article

First Page

1098

Last Page

1103

Recommended Citation

Bahaj, Ahmed S.; Alkaff, Haddad H.; Melebari, Bashair N.; Melebari, Anwar N.; Sayed, Suhail I.; Mujtaba, Syeddah S.; Abdelmonim, Sherif K.; Alghamdi, Saeed A.; Alghamdi, Fares E.; Alessa, Mohammad A.; Al-Tammas, Anas H.; Al-Zahrani, Rajab A.; Marglani, Osama A.; Heaphy, John C.; Bawazir, Osama A.; and Alherabi, Ameen Z. (2020) "Role of fine-needle aspiration cytology in evaluating thyroid nodules: A retrospective study from a tertiary care center of Western region, Saudi Arabia," Saudi Medical Journal: Vol. 41: Iss. 10, Article 10.
DOI: https://doi.org/10.15537/smj.2020.10.25417