Natural immunity to influenza A and B among Saudi blood donors in Al Madinah Al Munawarah, Saudi Arabia

Authors

• Waleed H. Mahallawi, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Nadir A. Ibrahim, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Khalid S. Alahmadi, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Abdullah K. Al-Harbi, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Mohammed A. Almughthawi, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Omar A. Alhazmi, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Fayez H. Alsehli, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
• Omar F. Khabour, From the Department of Medical Laboratory Technology (Mahallawi, Ibrahim, Alahmadi, Al-Harbi, Almughthawi), College of Applied Medical Sciences, Taibah University, from the General Directorate of Laboratories and Blood Banks (Alhazmi, Alsehli), Ministry of Health, Al Madinah Al Munawarah, Kingdom of Saudi Arabia and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan

Abstract

Objectives: To investigate the seroprevalence of influenza viruses (A and B) among blood donors in Kingdom of Saudi Arabia. Methods: The present investigation was conducted between April 2019 and July 2019. Participants were healthy adults recruited from the central blood bank Al Madinah Al Munawarah, Kingdom of Saudi Arabia. Immunoglobulin G (IgG) levels against influenza A and B were measured in serum samples using ELISA. Results: The results showed that 29.2% of the sample had significant concentrations of influenza A IgG antibody, whereas 38.6% had significant concentrations of influenza B IgG antibody. A strong correlation was found between the levels of influenza A and influenza B antibodies (r=0.708, p<0.001). The number of individuals identified as negative for influenza A IgG antibody increased with age (p<0.01). In addition, no correlations were identified between influenza A IgG and influenza B IgG and body mass index (BMI), (p>0.05). Finally, linear regression analysis showed that the level of influenza A antibody can be predicted by age (p<0.05) and body mass index (BMI) (p<0.05). Conclusion: Approximately one-third of Saudi Arabian adults presented significant levels of influenza A and B antibodies in our study. Demographic factors, including age and BMI, might contribute to influenza A antibody levels.

Article Type

Research Article

First Page

1301

Last Page

1307

Recommended Citation

Mahallawi, Waleed H.; Ibrahim, Nadir A.; Alahmadi, Khalid S.; Al-Harbi, Abdullah K.; Almughthawi, Mohammed A.; Alhazmi, Omar A.; Alsehli, Fayez H.; and Khabour, Omar F. (2020) "Natural immunity to influenza A and B among Saudi blood donors in Al Madinah Al Munawarah, Saudi Arabia," Saudi Medical Journal: Vol. 41: Iss. 12, Article 4.
DOI: https://doi.org/10.15537/smj.2020.12.05582