The association between plasma homocysteine level and metabolic syndrome: A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia

Authors

• Abdulkarim Saeed, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Mujahid Al Shehri, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Abdulghani Al Saleb, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Fatmah Othman, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Mohammed Al Hazmi, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Faris Al Amri, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Mazen Ferwana, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
• Maha Al Turki, College of Medicine (Saeed, Al Shehri, Al Saleb, Al Hazmi, Al Amri), King Saud bin Abdul Aziz University for Heath Science; from College of Applied Medical Sciences (Othman, Al Turki), King Saud bin Abdul Aziz University for Heath Science; from Department of Research Unit (Othman, Al Turki, Al Yousef), King Abdullah International Medical Research Center; from the Department of Family Medicine (Ferwana), King Abdulaziz Medical City; and from the Department of Oncology (Al Yousef), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia

Abstract

Objectives: To investigate the association between plasma homocysteine (Hcy) status and metabolic syndrome (MS) among Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia. Methods: A record-based cross-sectional study of 446 patients was carried out. All consecutive plasma Hcy levels from 2015 to 2018 were extracted. International Diabetes Federation criteria for MS were used to classify the patients. A multivariate regression model was developed to examine the associations between plasma Hcy and MS. Results: The mean plasma Hcy level was 10.52 µmol/L, and 40% of the patients exhibited elevated Hcy status. Male patients had significantly elevated Hcy levels compared to female patients ( p <0.001). In addition, plasma Hcy levels were significantly higher in patients diagnosed with diabetes ( p =0.021) and hypertension ( p <0.001). The prevalence of MS within the study population was 51%. Homocysteine levels were associated with the presence of MS independent of demographic, anthropometric and biochemical variables (odd ratio 1.018; 95% confidence intervals 1.011 -1.047). Conclusion: Plasma Hcy levels were elevated in 40% of the MS patients. Homocysteine had weak association with the presence of MS. Additionally, it was associated with some of its components individually. This study has raised the importance of investigating the association between Hcy status and MS among a representative sample of Saudi population. Additionally, examining possible association and interaction between Hcy level and specific component of MS is suggested to be explored in future studies.

Article Type

Research Article

First Page

947

Last Page

954

Recommended Citation

Saeed, Abdulkarim; Shehri, Mujahid Al; Saleb, Abdulghani Al; Othman, Fatmah; Hazmi, Mohammed Al; Amri, Faris Al; Ferwana, Mazen; and Turki, Maha Al (2020) "The association between plasma homocysteine level and metabolic syndrome: A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia," Saudi Medical Journal: Vol. 41: Iss. 9, Article 6.
DOI: https://doi.org/10.15537/smj.2020.9.25273