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Abstract

Objectives: To compare sedoanalgesia achieved using propofol-fentanyl-ketamine (PFK) combination with general anesthesia (GA) in terms of safety, hemodynamic stability, and perioperative complications. Methods: Patients in the GA group were anesthetized using fentanyl (2 μg kg-1) and propofol (2 mg kg-1). The PFK group was anesthetized using a mixture of which each one ml contains 0.005 mg of fentanyl, 5 mg of propofol, 5 mg of ketamine, and 2 mg of lidocaine. Patients received an initial dose of 0.05 ml kg-1, followed by 0.05 mg kg-1 60 seconds later. Maintenance boluses of 0.025 ml kg-1 were administered every 3-5 minutes. Respiration occurred spontaneously through a simple face mask with 3 L min-1 O 2 . Results: The GA group had 37 (37%) patients develop hypotensive episodes, compared to one (1%) episode in the PFK group ( p <0.001). Five (5%) patients in the PFK group had an episode of transient O 2 desaturation, compared to one (1%) patient in the GA group ( p =0.212). The duration of induction and termination of anesthesia were significantly shorter in the PFK group ( p <0.001). Conclusion: The PFK combination herein described is safe, effective, and provides intraoperative hemodynamic stability in patients with multiple comorbidities undergoing urological procedures.

Article Type

Research Article

First Page

629

Last Page

635

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