Association between nonalcoholic fatty liver disease and Helicobacter pylori infection in Dali City, China

Authors

• Ping Yan, From the Department of Gastroenterology (Yan, Li), from the Department of Clinical Laboratory (Yu, Zhao), the First Affiliated Hospital, Dali University, and from the Department of Hematology (Li), BaoShan People’s Hospital, Dali, China.
• Bocheng Yu, From the Department of Gastroenterology (Yan, Li), from the Department of Clinical Laboratory (Yu, Zhao), the First Affiliated Hospital, Dali University, and from the Department of Hematology (Li), BaoShan People’s Hospital, Dali, China.
• Min Li, From the Department of Gastroenterology (Yan, Li), from the Department of Clinical Laboratory (Yu, Zhao), the First Affiliated Hospital, Dali University, and from the Department of Hematology (Li), BaoShan People’s Hospital, Dali, China.
• Weidong Zhao, From the Department of Gastroenterology (Yan, Li), from the Department of Clinical Laboratory (Yu, Zhao), the First Affiliated Hospital, Dali University, and from the Department of Hematology (Li), BaoShan People’s Hospital, Dali, China.

Abstract

Objectives: To investigate whether gastric Helicobacter pylori (H. pylori ) infection is associated with the progress of nonalcoholic fatty liver disease (NAFLD) in Dali city, China. Methods: One thousand and one hundred eighty-five adults who had visited a health examination center were enrolled. Nonalcoholic fatty liver disease and H. pylori infection were assessed by abdominal color ultrasound and 13 C-urea breath test, respectively. Serum lipid metabolic indices were compared between NAFLD subjects without and with H. pylori infection. Results: The prevalence rate of NAFLD for the entire study population (n=1185) was 44.6% (n=529), including 167 women and 362 men. Among 529 NAFLD subjects, H. pylori was confirmed as a significant and independent risk factor for NAFLD (95% CI 1.02-1.79, p =0.036, OR =1.35). Compared with H. pylori non-infected individuals (n=721), higher contents of LDL-C ( p =0.012) along with TC ( p =0.014) were also observed in H. pylor i-infected individuals (n=464). Conclusion: A positive correlation is identified between H. pylori infection and NAFLD.

Article Type

Research Article

First Page

735

Last Page

741

Recommended Citation

Yan, Ping; Yu, Bocheng; Li, Min; and Zhao, Weidong (2021) "Association between nonalcoholic fatty liver disease and Helicobacter pylori infection in Dali City, China," Saudi Medical Journal: Vol. 42: Iss. 7, Article 6.
DOI: https://doi.org/10.15537/smj.2021.42.7.20210040