Enhanced external counterpulsation increases coronary flow reserve in coronary microvascular disease

Authors

• Qian Wang, From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
• Jia Hao, From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
• Wenjun Jiang, From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
• Qiang Tan, From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.

Abstract

Objectives: To investigates the outcomes of enhanced external counterpulsation (EECP) among coronary microvascular disease (CMD) patients. Methods: Coronary microvascular disease patients were separated into the EECP (n=41) and control cohorts (n=42). Prior to and following the 4-week EECP program, coronary flow reserve (CFR) was recorded using transthoracic Doppler echocardiography. The serum endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) contents were analyzed by ELISA. Quality of life (QoL) was assessed by the Seattle Angina Questionnaire (SAQ) and the Canadian Cardiovascular Society (CCS) angina class. Results: After four weeks, CFR was substantially enhanced in the EECP versus control cohort ( p <0.05). Endothelin-1 was strongly diminished whereas eNOS was considerably upregulated in the EECP cohort. EECP also enhanced patients’ SAQ scores and decreased the CCS angina class. Conclusion: Enhanced external counterpulsation may improve CFR and enhance the CMD patient QoL.

Article Type

Research Article

First Page

1277

Last Page

1282

Recommended Citation

Wang, Qian; Hao, Jia; Jiang, Wenjun; and Tan, Qiang (2023) "Enhanced external counterpulsation increases coronary flow reserve in coronary microvascular disease," Saudi Medical Journal: Vol. 44: Iss. 12, Article 10.
DOI: https://doi.org/10.15537/smj.2023.44.12.20230427