The association between inflammatory bowel disease and ischemic heart disease: A retrospective cohort study

Authors

• Mahmoud H. Mosli, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Dima M. Alsulami, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Yara K. Alghamdi, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Abdullah S. Badahdah, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Asmaa H. Alhibshi, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Thamer M. Alamri, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Maan S. Alkhattabi, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Khames T. Alzahrani, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Hadeel A. Alsufyani, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.
• Omar I. Saadah, From the Department of Internal Medicine (Mosli), Faculty of Medicine, from King Abdulaziz University Inflammatory Bowel Disease Research Group (Mosli, Saadah), from the College of Medicine (Alsulami, Alghamdi, Badahdah), King Abdulaziz University, from the Department of Internal Medicine (Alhibshi), King Abdulaziz Hospital, from the Department of Clinical Physiology (Alsufyani), King Abdulaziz University, from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, and from the Department of General Surgery (Alamri), King Abdulaziz Specialist Hospital, Taif, and from the Department of Endodontic (Alzahrani), King Faisal Specialist Hospital & Research Center, Riyadh, Kingdom of Saudi Arabia.

Abstract

ABSTRACT Objectives: To evaluate the association between Inflammatory bowel disease (IBD) and Ischemic heart disease (IHD). Methods: A retrospective cohort analysis included patients with and without IBD seen at the outpatient gastroenterology clinic of a large tertiary care hospital between January 2015 and October 2022. The primary outcome was the association between IBD and IHD, and the secondary outcome was predictors of IHD in patients with IBD. Results: The study included 400 patients; 291 were IBD patients, and 109 had other non-inflammatory GI disorders. The IBD group displayed significantly lower rates of hyperlipidemia (8.6% vs. 30.3%, p <0.001), diabetes mellitus (DM) (10% vs. 24.8%, p <0.001), and hypertension (11.7% vs. 32.1%, p <0.001) compared to the non-IBD group. Only 2.7% (n=8) of IBD patients developed IHD. Logistic regression analysis did not demonstrate a significant association between IBD and IHD ( p =0.932). Among classical risk factors, only hypertension (OR: 26.2, 95% CI: 2.14–661, p =0.016) and hyperlipidemia (OR: 10.5, 95% CI: 1.32–132, p =0.0405) significantly increased the risk of developing IHD among patients with IBD. Conclusion: In this cohort, there is no increased risk of developing IHD in patients with IBD compared to non-IBD patients.

Article Type

Research Article

First Page

1174

Last Page

1181

Recommended Citation

Mosli, Mahmoud H.; Alsulami, Dima M.; Alghamdi, Yara K.; Badahdah, Abdullah S.; Alhibshi, Asmaa H.; Alamri, Thamer M.; Alkhattabi, Maan S.; Alzahrani, Khames T.; Alsufyani, Hadeel A.; and Saadah, Omar I. (2025) "The association between inflammatory bowel disease and ischemic heart disease: A retrospective cohort study," Saudi Medical Journal: Vol. 46: Iss. 10, Article 9.
DOI: https://doi.org/10.15537/smj.2025.46.10.20250181