Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin

Authors

• Muhammad U. Afzal, From School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
• Naam B. Adeeb, From School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
• Nur F. Musa, From School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
• Dzul A. Noor, From School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.

Abstract

ABSTRACT Objective: To explore the allele frequency and associations between the presence of single nucleotide polymorphisms (SNP) in the ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on lipid-lowering efficacy of atorvastatin among Malaysian male patients. Method: The study included 64 subjects from a previous genetic association study among male patients who were on atorvastatin. The study was carried out at HUSM, Kelantan, Malaysia from December 2023 to October 2024. The patients were split into 2 groups, each consisting of 32 subjects such as controlled (LDL level <3 mmol/L) and uncontrolled (LDL level >3 mmol/L). After genotyping each participant, the influence on their lipid profile was determined. Results: The genotype frequency of genes ABCB1 (rs1045642) and CYP7A1 (rs3808607) was higher in the variant allele GG (37.5%) and TT (36%), respectively, compared with the reference allele. Patients with the variant genotype of ABCB1 and reference genotype of CYP7A1 were more likely to be observed in the controlled group in response to atorvastatin. A significant correlation was found between the genotype ABCB1 (rs1045642) and HDL levels (p=0.045). Conclusion: The allele frequency of the heterozygous group was higher in both studied SNPs. The variant allele of gene ABCB1 and the reference allele of CYP7A1 showed a more favorable lipid profile.

Article Type

Research Article

First Page

898

Last Page

906

Recommended Citation

Afzal, Muhammad U.; Adeeb, Naam B.; Musa, Nur F.; and Noor, Dzul A. (2025) "Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin," Saudi Medical Journal: Vol. 46: Iss. 8, Article 6.
DOI: https://doi.org/10.15537/smj.2025.46.8.20250310