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Abstract

Objectives: To determine the prevalence of hyperprolactinemia among infertile women and assess its association with menstrual irregularities and hypothyroidism in a tertiary-care setting in Riyadh, Saudi Arabia.

Methods: A cross-sectional study was conducted between September 2022 and August 2023 at the Reproductive Endocrinology and IVF Unit, King Abdulaziz Medical City, Riyadh. Electronic medical records of 480 infertile women who met the inclusion criteria were reviewed. Data on demographic characteristics, infertility type, thyroid status, and serum prolactin levels were collected and analyzed using SAS version 9.4. Statistical significance was set at p < 0.05.

Results: Hyperprolactinemia was identified in 27.7% of infertile women, most commonly in the age group 31–40 years (p = 0.006). Hypothyroidism was present in 17.5% of the study population, with hyperprolactinemia observed in 22.6% of these patients (p = 0.33). Although prolactin levels significantly differed between women with regular and irregular cycles (p = 0.03), the frequency of hyperprolactinemia was similar (p = 0.44). Menstrual irregularity was more closely linked with higher BMI and LH levels.

Conclusion: Hyperprolactinemia is a common finding among infertile women in Saudi Arabia. However, no significant association was observed between hyperprolactinemia and hypothyroidism or menstrual irregularities. Routine screening for serum prolactin levels in infertility evaluations is recommended to ensure timely diagnosis and management.

Article Type

Original Study

First Page

1240

Last Page

1245

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